Talk:Lauwereyns2002

In response to some helpful comments from Matt Brush:

1. About the second figure Matt said: "Also, it is not clear to me what in what part of the investigation processes like data analysis, data interpretation, and drawing conclusions occur. During the study design execution?  Or is there some additional part of an investigation besides planning, execution, and reporting that would cover these processes?"

I haven't included this in the model so far, first because it wasn't in the published case study, but second because I don't know how to model it yet. I definitely think the analysis stage should be modelled, and I would prefer to model it as a separate part of the investigation that takes place after the study design execution.

I'll try to add a model of the analysis stage as presented in the "Data Analysis" section of the original paper, but I doubt it will include sufficient detail. Perhaps there's someone on the list who's familiar with the original study and can help with this?

2. Breaking with the original case, I think that the L2002 study enrolment *realizes* Albert's subject role. Both Matt and the published OBI paper say that the stimulus or some other part of the execution realizes the role. (Matt mentioned some other nuances and ideas in his comments that he might want to elaborate on.) I'd like to hear other views on this. In defence of my own view, I'd say that the a subject in the control arm of a study is still a subject by virtue of his enrollment, even if he receives no intervention and is only assayed. And on my view subject enrolment is parallel to specimen creation in realizing the role.

In response to some additional comments from Jie Zheng:

3. I've modelled the study design as just having protocols as its parts, but since it's subtype of plan specification it should also have an action specification and an objective specification. It's not clear to me what those should be -- shouldn't the protocols cover everything? Perhaps study design should be promoted to a directive information entity.